ISA-2011B for Dummies
The neurologic phenotype in SCA8 BAC growth although not BAC Handle strains shown the pathogenicity from the (CTG-CAG)n growth. Also, the expression of noncoding (CUG)n expansion ATXN8OS transcripts and the discovery of intranuclear polyglutamine inclusions prompt that SCA8 pathogenesis involves poisonous gain-of-operate mechanisms at both of those